In the fictional town of Agrestic, California, Nancy Botwin's (Mary-Louise Parker) world has "gone to pot." Nancy's husband, Judah (Jeffrey Dean Morgan), has just died of a heart attack, leaving her to provide for her two boys, Silas (Hunter Parrish) and Shane (Alexander Gould). The problem is she's broke. Nancy "deals" with her severe financial problems by taking the "high" road less taken to support her family and maintain their upper-middle class lifestyle. But flat sales and growing competition from a medicinal dispensary requires Nancy to do what every stressed-out-pot-dealing mother would do ...she turns to tricks, er "treats." The former soccer mom starts to think outside the little boxes, or rather, "little baggies" by whipping up some of those super-addictive brownies …the kind Betty Crocker never dared bake. The brownies are a hit! So encouraged by her accountant and respected city council man, Doug Wilson (Kevin Nealon), Nancy opens a retail bakery as a front for her drug sales. And so in a few, simple, twisted steps, dealing marijuana becomes the only way that this mother of two can deal with the highs and lows of everyday life.
Nancy Botwin struggles with the sudden death of her husband and agonizes over how she'll support and raise two young boys on her own. Without any discernable career skills, the widow Botwin finds good paying work as the local pot dealer in the pristine, new LA suburb known as Agrestic. There's definitely a double meaning when this girl puts on her Mary Janes.
Celia Hodes is the imperious, calculating and superficial PTA president and fellow super mom. She is Nancy's friend and nemesis, tightly wound into one darn good Machiavellian manipulator, capable of fiendishness and friendship.
Nearly perpetually stoned, Doug Wilson is Nancy's accountant and business advisor, not to mention one of her best cannabis clients. He's good-hearted and well-intended but his advice and counsel is not usually the result of clear thinking.
Andy Botwin, Nancy's aimless brother-in-law, with no visible means of supporting himself, moves in with Nancy and the boys. He's obsessed with get-rich-quick schemes until he finds out about Nancy's lucrative pot business, and invites himself to become her partner.
15-year-old Silas, Nancy's oldest son, is forced to become the man of the house after his father passes away. His grief and teenage insecurities have adverse affects on girlfriends, friends and family.
Shane Botwin, Nancy's loveable and imaginative youngest son, is the most vocal in grieving for his father and often acts out in bizarre and sometimes disturbing ways.